Since the engineered skin graft can have a longer lifespan for the mice, it is conceived to use the technique to treat a range of conditions in human as well.
The findings of the study
The clustered regularly interspaced short palindromic repeats or CRISPR technology was used to create a skin graft by manipulating the genome with a greater efficacy. Xiaoyang Wu, assistant professor of the research, believes that this finding could turn out to be a cheaper form of stem cell transplant with a better outcome. If its efficacy stands potential for humans, it is effective in warding off a wide range of conditions including genetic disorder hemophilia.
Why Engineered Skin Graft a Safer and Better Gene Therapy Option
The gene editing using CRISPR is quicker and safer as compared to current methods of DNA patch editing in humans as they pose some risks. The administration process of the skin grafts in humans is easier, while other processes of the introduction of genes require a viral delivery, prompting for the development of tumors, and also interfering with immune responses in them.
As far as the engineered skin graft is concerned, they are easily accessible, and the risks are more likely to be removed with a quicker effect.
Observation of The Study
Using CRISPR technology, an engineered skin graft was developed to use on the mice in the lab. It targeted the mutations in the GLP-1 gene to stabilize it and secrete it in the bloodstream. Mice having skin grafts dropped their glucose levels as their insulin level rose on a normal diet. While mice on a high fat diet became obese, but their weight reduced once an administration of GLP-1 in their bloodstream was introduced coupled with a drug doxycycline. So, the engineered skin graft technology is promising not only for diabetes, but also for obesity.